Cover Features
Recent Representative Publications
23. Quanyin Hu+, Hongjun Li+, Edikan Ogunnaike, Qian Chen, Huitong Ruan, Sarah Ahn, Elena Dukhovlinova, Kang Yang, Di Wen, Gianpietro Dotti*, Zhen Gu*, “Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets", Nature Biomedical Engineering , 5, 1038-1047, 2021 Link.
22. Tianyuan Ci+, Hongjun Li+, Guojun Chen, Zejun Wang, Jinqiang Wang, Peter Abdou, Yiming Tu, Gianpietro Dotti, and Zhen Gu*, “Cryo-shocked cancer cells for targeted drug delivery and vaccination", Science Advances , 6(eabc3013), 2020 Link.
21. Zejun Wang, Jinqiang Wang, Hongjun Li, Jicheng Yu, Guojun Chen, Anna R. Kahkoska, Valerie Wu, Yi Zeng, Di Wen, Jayson R. Miedema, John B. Buse, and Zhen Gu*, “Dual self-regulated delivery of insulin and glucagon by a hybrid patch", Proceedings of the National Academy of Sciences U.S.A. (PNAS), 117(29512), 2020 Link.
20. Jicheng Yu, Jinqiang Wang, Yuqi Zhang, Guojun Chen, Weiwei Mao, Yanqi Ye, Anna R. Kahkoska, John B. Buse, Robert Langer, and Zhen Gu*, “Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs", Nature Biomedical Engineering, 4(499), 2020 Link. Watch Video Introduction.
19. Guojun Chen+, Zhitong Chen+, Di Wen, Zejun Wang, Hongjun Li, Yi Zeng, Gianpietro Dotti, Richard Wirz*, and Zhen Gu*, “Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 7(3687), 2020. Link
18. Quan Zhou+, Shiqun Shao+, Jinqiang Wang, Changhuo Xu, Jiajia Xiang, Ying Piao, Zhuxian Zhou, Qingsong Yu, Jianbin Tang, Xiangrui Liu, Zhihua Gan, Ran Mo, Zhen Gu*, and Youqing Shen*, “Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy”, Nature Nanotechnology, 14(799), 2019. Link
17. Di Wen, Jinqiang Wang, George Van Den Driessche, Qian Chen, Yuqi Zhang, Guojun Chen, Hongjun Li, Jennifer Soto, Ming Liu, Masao Ohashi, Zejun Wang, Peter Abdou, Quanyin Hu, Gianpietro Dotti, Song Li, Denis Fourches, and Zhen Gu*, “Adipocytes as Anticancer Drug Delivery Depot”, Matter, 5(1203), 2019. (Cover) Link
16. Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Anna R.Kahkoska, Zejun Wang, Jun Fang, Julian P. Whitelegge, Song Li, John B. Buse, and Zhen Gu*, “Glucose Transporter Inhibitor-Conjugated Insulin Mitigates Hypoglycemia”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 22(10744), 2019. Link
15. Zhaowei Chen, Zejun Wang, and Zhen Gu*, “Bioinspired and Biomimetic Nanomedicines”, Accounts of Chemical Research, 5(1255), 2019. Link
14. Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu, Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Yifei Lu, Guang Yang, Chen Jiang, Jun Wang, Gianpietro Dotti and Zhen Gu*, “In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment”, Nature Nanotechnology, 14(89), 2019. Link (View PDF) Also see: Nat. Nano's highlights
13. Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang, and Zhen Gu*, “Conjugation of Haematopoietic Stem Cells and Platelets Decorated with Anti-PD-1 Antibodies Augments Anti-leukaemia Efficacy”, Nature Biomedical Engineering, 2(831), 2018. Link (View PDF) also see: Nat. Biomed. Eng's highlight (View PDF)
12. Zhaowei Chen, Jinqiang Wang, Wujin Sun, Edikan Archibong, Anna R. Kahkoska, Xudong Zhang, Yue Lu, Frances S. Ligler, John B. Buse, Zhen Gu*, “Synthetic β-cells for Fusion-Mediated Dynamic Insulin Secretion”, Nature Chemical Biology, 14(86), 2018. Link also see: JAMA's highlight
11. Chao Wang+, Jinqiang Wang+, Xudong Zhang, Shuangjiang Yu, Di Wen, Quanyin Hu, Yanqi Ye, Hunter Bomba, Xiuli Hu, Zhuang Liu, Gianpietro Dotti, Zhen Gu*, “In Situ Formed Reactive Oxygen Species-Responsive Scaffold with Gemcitabine and Checkpoint Inhibitor for Combination Therapy”, Science Translational Medicine, 10(eaan3682), 2018. Link also see: Nat. Rev. Cancer's highlight
10. Jicheng Yu, Yuqi Zhang, Yanqi Ye, Rocco DiSanto, Wujin Sun, Davis Ranson, Frances Ligler, John Buse, Zhen Gu*, “Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 112(8260), 2015. Link also see: Nature's highlight
9. Chao Wang, Wujin Sun, Yanqi Ye, Quanyin Hu, Hunter Bomba, Zhen Gu*, " In situ Activation of Platelets with Checkpoint Inhibitors for Post-Surgical Cancer Immunotherapy", Nature Biomedical Engineering, 0011, 2017. Link (View PDF) also see: Nat. Rev. Clin. Oncol's highlight (View PDF)
8. Yue Lu, Alex Aimetti, Robert Langer*, Zhen Gu*, “Bioresponsive Materials”, Nature Reviews Materials, 2(16075), 2016 Link (View PDF)
7. Naveed Bakh, Mabel Cortinas, Michael Weiss, Robert Langer, Daniel Anderson, Zhen Gu, Sanjoy Dutta, Michael Strano*, “Glucose-Responsive Insulin by Molecular and physical Design”, Nature Chemistry, 9(937), 2017. Link
6. Jicheng Yu, Yuqi Zhang, Zhen Gu*, “Advances in Bioresponsive Closed-loop Drug Delivery Systems", International Journal of Pharmaceutics, 544(350), 2018. Link
5. Wujin Sun, Wenyan Ji, Quanyin Hu, Zhen Gu*, “Leveraging Physiology for Precision Drug Delivery”, Physiological Reviews, 97(189), 2017. Link
4. Yuqi Zhang, Jicheng Yu, Hunter Bomba, Yong Zhu, Zhen Gu*, “Mechanical Force-Triggered Drug Delivery”, Chemical Reviews, 116(19), 2016. Link
3. Jicheng Yu, Yuqi Zhang, Anna R. Kahkoska, Zhen Gu*, “Bioresponsive Transcutaneous Patches", Current Opinion in Biotechnology, 48(28), 2017. Link
2. Yue Lu, Quanyin Hu, Yiliang Lin, Dennis B. Pacardo, Chao Wang, Wujin Sun, Frances S. Ligler, Michael D. Dickey, Zhen Gu*, “Transformable Liquid-Metal Nanomedicine”, Nature Communications, 6(10066), 2015. Link
1. Wujin Sun, Wenyan Ji, Jordan M. Hall, Quanyin Hu, Chao Wang, Chase L. Beisel, Zhen Gu*, “Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing”, Angewandte Chemie International Edition, 127(12197), 2015. Link
